Description University of Colorado Anschutz Medical Campus
Department: Medicine, Division of Renal Diseases and Hypertension
Job Title: Postdoctoral Fellow
Position #00633744 – Requisition #32053
Job Summary:
The Weiser-Evans laboratory focuses on vascular biology, with particular emphasis on smooth muscle cell (SMC) signaling and understanding the regulation of SMC phenotypic modulation in disease. We have developed novel genetic mouse models that allow inducible smooth muscle-specific knockout or overexpression of specific genes involved in progression of vascular disease. We routinely use a SMC fate-mapping approach developed in our lab to track mature SMCs in the setting of disease progression even if they lose all detectable expression of traditional SMC markers. This approach facilitates molecular analyses such as RNA-Seq, ChIP, and CyTOF mass cytometry. In vivo mouse genetic approaches are complemented by in vitro studies using cultured SMCs as well as co-culture systems that allow us to examine crosstalk between SMCs and inflammatory cells (e.g. macrophages).
Key Responsibilities:
Transgenic mouse colony management and genotyping (5%)
Perform surgery in mouse models of cardiovascular diseases (10%)
Mouse sacrifice and tissue harvest (20%)
Immunohistochemical and immunofluorescence staining (10%)
Microscopic imaging, confocal imaging and image analysis (20%)
Cell culture maintenance and in vitro experiments (5%)
Single cell suspension preparation, flow cytometry and cell sorting (10%)
Molecular and biochemical assays, such as western blotting, qPCR, molecular cloning. (10%)
Bioinformatics analysis of next-generation sequencing data (10%)
Why Join Us:
The Division of Renal Diseases and Hypertension at the University of Colorado has a longstanding international reputation for excellence in research. The Division faculty are well funded with total annual funding in excess of $12 million, including NIH, VA, DoD, corporate and foundation sources, placing the Division in the top ten in the country for research funding. The Division has been at the forefront of advances in nephrology, specifically in the areas related to acute kidney injury, polycystic kidney disease, hypertension, fluid and electrolyte disorders, and glomerulonephritis.
The Division holds an NIH T32 Training grant and has so for over 44 years. Our faculty and fellows continue our research mission in basic science, translational and clinical research. We are committed to training and cultivating the next generation of researchers in nephrology.
The University of Colorado offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, tuition benefits, ECO pass, paid time off – vacation, sick, and holidays and more. To see what benefits are available, please visit: https://apptrkr.com/get_redirect.php?id=4849667&targetURL=Postdoctoral Fellow
Position #00633744 – Requisition #32053
Job Summary:
The Weiser-Evans laboratory focuses on vascular biology, with particular emphasis on smooth muscle cell (SMC) signaling and understanding the regulation of SMC phenotypic modulation in disease. We have developed novel genetic mouse models that allow inducible smooth muscle-specific knockout or overexpression of specific genes involved in progression of vascular disease. We routinely use a SMC fate-mapping approach developed in our lab to track mature SMCs in the setting of disease progression even if they lose all detectable expression of traditional SMC markers. This approach facilitates molecular analyses such as RNA-Seq, ChIP, and CyTOF mass cytometry. In vivo mouse genetic approaches are complemented by in vitro studies using cultured SMCs as well as co-culture systems that allow us to examine crosstalk between SMCs and inflammatory cells (e.g. macrophages).
Key Responsibilities:
Transgenic mouse colony management and genotyping (5%)
Perform surgery in mouse models of cardiovascular diseases (10%)
Mouse sacrifice and tissue harvest (20%)
Immunohistochemical and immunofluorescence staining (10%)
Microscopic imaging, confocal imaging and image analysis (20%)
Cell culture maintenance and in vitro experiments (5%)
Single cell suspension preparation, flow cytometry and cell sorting (10%)
Molecular and biochemical assays, such as western blotting, qPCR, molecular cloning. (10%)
Bioinformatics analysis of next-generation sequencing data (10%)
Why Join Us:
The Division of Renal Diseases and Hypertension at the University of Colorado has a longstanding international reputation for excellence in research. The Division faculty are well funded with total annual funding in excess of $12 million, including NIH, VA, DoD, corporate and foundation sources, placing the Division in the top ten in the country for research funding. The Division has been at the forefront of advances in nephrology, specifically in the areas related to acute kidney injury, polycystic kidney disease, hypertension, fluid and electrolyte disorders, and glomerulonephritis.
The Division holds an NIH T32 Training grant and has so for over 44 years. Our faculty and fellows continue our research mission in basic science, translational and clinical research. We are committed to training and cultivating the next generation of researchers in nephrology.
The University of Colorado offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, tuition benefits, ECO pass, paid time off – vacation, sick, and holidays and more. To see what benefits are available, please visit: https://www.cu.edu/employee-services/benefits-wellness.
Diversity and Equity:
The University of Colorado Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities, persons within the LGBTQ+ community and all veterans. The University of Colorado is committed to diversity and equality in education and employment.
Qualifications:
Minimum Qualifications: Applicants must meet minimum qualifications at the time of hire.
Education:
PhD, MD, or PhD/MD preferably in the cardiovascular or related field
Experience:
Two years of experience managing genetic mouse colonies and animal handling/surgery.
Three years of experience with standard molecular and cellular biology microscopy and cell culture techniques.
Preferred Qualifications:
Experience in vascular biology.
Proven experience and familiarity with confocal/fluorescent microscopy imaging.
Basic knowledge in bioinformatics data analysis.
Knowledge, Skills and Abilities:
Excellent communication skills using the English language.
The ability to work independently within the research laboratory
Team player with strong interpersonal skills.
How to Apply:
For full consideration, please submit the following document(s):
A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position
Curriculum vitae / Resume
Five professional references including name, address, phone number (mobile number if appropriate), and email address
Applications are accepted electronically ONLY at https://apptrkr.com/get_redirect.php?id=4849667&targetURL=PhD, MD, or PhD/MD preferably in the cardiovascular or related field
Experience:
Two years of experience managing genetic mouse colonies and animal handling/surgery.
Three years of experience with standard molecular and cellular biology microscopy and cell culture techniques.
Preferred Qualifications:
Experience in vascular biology.
Proven experience and familiarity with confocal/fluorescent microscopy imaging.
Basic knowledge in bioinformatics data analysis.
Knowledge, Skills and Abilities:
Excellent communication skills using the English language.
The ability to work independently within the research laboratory
Team player with strong interpersonal skills.
How to Apply:
For full consideration, please submit the following document(s):
A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position
Curriculum vitae / Resume
Five professional references including name, address, phone number (mobile number if appropriate), and email address
Questions should be directed to: Betsy Pike, Renal Division Human Resources, betsy.pike@cuanschutz.edu
Screening of Applications Begins:
Immediately and continues until position is filled.
Anticipated Pay Range:
The starting salary range (or hiring range) for this position has been established as HIRING RANGE:
NIH Stipend levels:
Career Level Years of Experience Stipend for FY 23 Monthly Stipend
Postdoctoral 0 $56,484 $4,707
Postdoctoral 1 $56,880 $4,740
Postdoctoral 2 $57,300 $4,775
Postdoctoral 3 $59,592 $4,966
Postdoctoral 4 $61,572 $5,131
Postdoctoral 5 $63,852 $5,321
Postdoctoral 6 $66,228 $5,519
Postdoctoral 7 $68,604 $5,717
The above salary range (or hiring range) represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting. This position is not eligible for overtime compensation unless it is non-exempt.
Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.
The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at hr.adacoordinator@ucdenver.edu.
Background Check Statement:
The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.
Vaccination Statement:
CU Anschutz strongly encourages vaccination against the COVID-19 virus and other vaccine preventable diseases. If you work, visit, or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz, you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work, visit, or volunteer, respectively. In addition, if you work in certain research areas or perform certain safety sensitive job duties, you must enroll in the occupational health medical surveillance program.
Application Materials Required: Cover Letter, Resume/CV, List of References
Job Category: Faculty
Primary Location: Aurora Department: U0001 -- Anschutz Med Campus or Denver - 20224 - SOM-MED-REN GENERAL OPERATIONS
Post-Doctoral Fellow - 32053 Faculty