Job Details

Post Doc Res Assoc

Position Number: 6194536
Location: Salt Lake City, UT
Position Type: Laboratory and Research

Post Doc Res Assoc

Job Summary

We are seeking a highly motivated post-doctoral fellow to join our research program for a position in the laboratory of Dr. Jens Lohr at Huntsman Cancer Institute. Our basic and translational research program aims to understand the evolution and treatment resistance of hematologic cancers by leveraging advanced next-generation sequencing technologies. We utilize sophisticated approaches, including single-cell multiparameter sequencing and flow cytometry, to analyze circulating and bone marrow tumor cells with high precision. The ultimate goal of highly granular characterization of tumors and their microenvironment is to elucidate the mechanisms of drug resistance in hematologic malignancies and facilitate the discovery of novel immunotherapies. Our research focuses on several key objectives, including: 1) Identifying the regulators of treatment response and resistance in multiple myeloma, 2) Leveraging liquid biopsy as a tool for clinical decision-making and evaluating therapeutic efficacy, 3) Advancing the development of more effective immunotherapies, including CAR T cell therapies. The postdoctoral fellow will interact and collaborate closely with other laboratory-based scientists and computational biologists across Huntsman Cancer Institute and the University of Utah and will be involved in a series of research activities including cellular and molecular cancer biology; low input genomics; epigenetics

Huntsman Cancer Institute is committed to cancer prevention, care, and survivorship for all communities within the area we serve - which includes Idaho, Montana, Nevada, Utah, and Wyoming - with impact worldwide.

In your cover letter or during your interview process, we invite you to share how your professional experiences have prepared you to serve as a member of our team as we work to reduce the cancer burden experienced by all people and communities. This may include description of your prior experiences related to research, prevention, clinical care, community engagement/outreach, training, administration, or other areas relevant to Huntsman Cancer Institute's mission and this position.

Responsibilities
Essential Functions1. Process and analyze liquid biopsy samples, integrating molecular and cellular insights to track disease progression and therapeutic response.2. Optimize and troubleshoot methodologies for single-cell multiparameter sequencing, flow cytometry, cfDNA analysis and other relevant assays.3. Perform and interpret next-generation sequencing (NGS) data from circulating and bone marrow tumor cells.4. Work with bioinformatics tools to analyze single-cell and bulk sequencing datasets, identifying key genomic and transcriptomic alterations.5. Coordinate with clinical teams to obtain and handle patient-derived samples in compliance with ethical and regulatory guidelines.6. Utilize flow cytometry and single-cell RNA sequencing (scRNA-seq) to dissect immune cell populations and their role in drug resistance.7. Work closely with interdisciplinary teams, including clinicians, computational biologists, and immunologists.8. Present research findings at lab meetings, conferences, and collaborations.9. Assist in mentoring junior researchers and maintaining lab operations.10. Integrate multi-modal data (e.g., genomics, transcriptomics, proteomics) to identify biomarkers of treatment resistance.11. Prepare and submit research manuscripts for publication in high-impact journals.12. Contribute to grant proposals and progress reports to secure research funding.This job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

Problem Solving
1. Must possess a high level of initiative and the ability to work with little supervision while adhering to Standard Operation Procedures.2. Must have excellent written, documentation, and oral communication skills.3. Must possess strong interpersonal, organizational, and analytical skills, including the ability to handle a variety of tasks in a fast-paced environment.4. Proactive in identifying problems and solutions to address them.5. Must be an exceptional team player.6. Address scientific and technical challenges related to immune and cancer cell characterization

Work Environment and Level of Frequency that may be required
Nearly Continuously: Laboratory environment.

Physical Requirements and Level of Frequency that may be required
Nearly Continuously: Sitting, hearing, listening, talking. Often: Repetitive hand motion (such as pipetting typing), walking.Occasionally: Bending, reaching overhead.

Minimum Qualifications
1. PhD, MD, or MD/PhD 2. Candidates with solid background in molecular biology and immunology and an interest in translational research are encouraged to apply. Candidates with demonstrated ability for completing complex research projects during their MD, PhD, MD/PhD and significant experience in standard laboratory techniques (including flow cytometry, tissue culture, PCR, western blots, etc.) will be considered. 3. Basic computational skills to analyze and interpret next generation sequencing and multi-dimensional flow cytometry data4. Experience with cell-based potency assays, engineered immune cells, next-generation sequencing (NGS) and genome editing (CRISPR/Cas9) is a plus5. Excellent written and oral communication skills6. Strong organizational skills, including the ability to handle a variety of tasks in a fast-paced environment required7. Strong analytical and problem-solving abilities with a data-driven approach8. Ability to work both independently and collaboratively in a fast-paced research and manufacturing environment.9. Please include a CV, a letter of interest and a list of three references in the application. Minimum two-year commitment is required.

Preferences

Special Instructions

Requisition Number: PRN41364B
Full Time or Part Time? Full Time
Work Schedule Summary:
Department: 02346 - HCI Jens Lohr Lab
Location: Campus
Pay Rate Range: 20000 to 500000
Close Date: 6/30/2025
Open Until Filled:

To apply, visit https://utah.peopleadmin.com/postings/179617